Has many complex proteins and so have a robust system for heat-shock protein assisted folding3/2/2024 ![]() Understanding the dynamics of protein-protein interactions (PPIs) leading to multi-protein complexes is better suited to characterize multi-locus incompatibilities, compared to studying them with traditional approaches of genetics and molecular biology. Many of these multi-locus incompatibilities show visible defects, only in the presence of all the interactions, making it hard to characterize. Such reciprocal-sign epistasis between inter-specific alleles is not limited to incompatible interactions between just one gene pair and, usually involves multiple genes. When two species mate, the hybrid offspring are usually inviable or sterile because of large-scale differences in the genetic makeup between the two parents causing incompatible genetic interactions. Multi-protein complexes are an admixture of subunits, change their interaction partners, and modulate their functions and cellular physiology in response to environmental changes. Proteins are the workhorses of the cell and execute many of their functions by interacting with other proteins forming protein complexes. 4Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan. ![]() 3Division of Head and Neck Surgery, Department of Otolaryngology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.2Department of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.1Division of Biological and Life Sciences, School of Arts and Sciences, Ahmedabad University, Ahmedabad, India. ![]()
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